Medicinal Chemistry & Chemical Biology, Contributed Talk (15min)

Achiral Supercritical fluid Chromatography (SFC) for the Purification of Pharmaceuticals

J. Reilly1
1Novartis Institute of Biomedical Research

With large quantities of small scale (<1000mg) compounds typically being needed to be purified and evaluated for discovery in-vitro and in-vivo testing regimes, a chromatographic purification technique needs to be easily integrated into discovery chemistry laboratories and highly reproducible. Within Separation Sciences departments in Pharmaceutical Industry there are a range of methodologies focused on the analytical separation and purification to isolate pure products. At Novartis, the integration of Supercritical fluid chromatography (SFC) for achiral separations has several advantages, such as faster run times, shorter equilibration times, reduced solvent consumption, and in preparative applications, fast solvent removal. SFC has rapidly become a very attractive alternative to Normal Phase and Reverse Phase purification for achiral samples and example separations are demonstrated